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                      化学交联结合质谱技术(chemical cross-linking coupled with mass spectrometry,CXMS)技术在近十年内得到了蓬勩I展。被广泛应用于蛋白质结构鉴定和蛋白质相互作用分析。目剡CXMS技术在实际应用存在一定的局限性:1、复杂样品处理效率偏低;2、能够提供的交联信息有限ٿ。该技术发展的最大瓶颈已经体现在有限的化学交联剂选择和交联效率上。百灵威作为专业供应商,提供新型化学交联剂Leiker和d6-Leiker,具有可富⛆、可切断、可定量的作?sup>[1]?/span>

                ?strong> Leiker具有高效的富集功胨,比传统交联剂有更髨的效率

                Figure 1. Leiker(2138035) allowed near 100% enrichment of target peptides from a cross-linked ten-protein mixture diluted with increasing amounts of non-cross-linked E. coli lysates[1].

                ?/span> Leiker可以显著提高所能鉴定到的交联肽段数?/span>

                Figure 2. CXMS analyses of E. coli and C. elegans lysates. The best protein-protein interaction cluster extracted from the Leiker-identified or BS3(146482)-identified (Yang et al., 2012) [2]inter-links from E. coli whole-cell lysates[1].

                ?strong style="font-family: arial, helvetica, sans-serif; font-size: 13.3333px; text-align: left;"> Leiker可以进行定量CXMS研究

                Figure 3. Quantitative CXMS analysis of the L7Ae-RNA complex. Reciprocal labeling of RNA-free (F) and RNA-bound (B) L7Ae with [d0]/[d6]-Leiker(2322681)[1].

                References

                [1] Tan D, Li Q, Zhang M J, et al. Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states[J]. Elife Sciences, 2016, 5.

                [2] Yang B, Wu Y J, Zhu M, et al. Identification of cross-linked peptides from complex samples.[J]. Nature Methods, 2012, 9(9):904-906.

                ?新型蛋白质交联剂

                营销编号

                产品名称

                中文名称

                包装规格

                2138035

                Leiker, 95%

                赖С酸特异性可富集型交联剂

                5 mg
                10 mg

                2322681

                d6-Leiker, 95%

                d6-赖氨酸特异性可富集型交联剂

                5 mg
                10 mg

                ?nbsp;其他交联剂系列产?/strong>

                产品编号

                产品名称

                CAS

                包装规格

                350636

                4-Benzoylbenzoic acid N-succinimidyl ester, 97%

                91990-88-4

                50 mg
                250 mg

                146482

                Bis(sulfosuccinimidyl) suberate sodium salt, BS3, 90%

                82436-77-9

                25 mg
                100 mg

                296329

                Di(N-succinimidyl) 3,3'-dithiodipropionate, DTSP, 97%

                57757-57-0

                1 g
                5 g

                456454

                Di(N-succinimidyl) glutarate, DSG, 97%

                79642-50-5

                50 mg
                250 mg

                253405

                Di(N-succinimidyl) suberate, DSS, 98%

                68528-80-3

                1 g
                5 g

                1410146

                Disuccinimidyl tartrate, DST, 95%

                N/A

                5 mg
                25 mg

                792543

                3,3'-dithiobispropionic acid bis-sulfosuccinimidyl ester, DTSSP, 90%

                81069-02-5

                25 mg
                100 mg

                444282

                N-Succinimidyl iodoacetate, 95%

                39028-27-8

                100 mg
                500 mg

                551313

                Succinimidyl 3-(2-Pyridyldithio)Propionate, SPDP, 97%

                68181-17-9

                100 mg

                ?相关产品

                产品编号

                英文名称

                中文名称

                CAS

                649777

                Acrylamide/?Bis-?acrylamide Solution, 29:1, 40%

                丙烯酰訌/双丙烯酰胺溶?/span>

                N/A

                398539

                Aprotinin, 6000 U/mg

                抑肽?/span>

                9087-70-1

                3922801

                BCA Protein Assay Macro Kit

                蛋白质定量试剂盒

                N/A

                266630

                Benzamidine hydrochloride, 99%

                苯甲脒盐酸盐

                1670-14-0

                1914018

                CAPS Buffer

                CAPS 缓冲?/span>

                N/A

                327499

                Coomassie Brilliant Blue G

                考马斯亮?/span>G

                6104-58-1

                415951

                Dithiothreitol, 99%

                二硫苏糖?/span>

                3483-12-3

                1914020

                Phosphate Buffered Saline, 10×

                PBS缓冲?/span>

                N/A

                3910101

                Protease Inhibitor Mix G

                Cocktail蛋白酡抑制剂G

                N/A

                3910201

                Protease Inhibitor Mix M

                Cocktail蛋白酡抑制剂M

                N/A

                1201851

                Protein Color Marker, M.W. 1,200 - 31,000 Da

                蛋白预染Marker

                N/A

                1914019

                SSC Buffer, 20×

                SSC 缓冲?/span>

                N/A

                1913953

                Tris-Glycine-SDS Running Buffer, 10×

                Tris-Glycine-SDS电泳缓冲?/span>

                N/A

                954773

                Trypsin, 2500 units/mg

                胰蛋y白酶

                9002-07-7

                ?/span> 其他配套产品?/strong>

                百灵威高敡酶制剂

                百灵娡ԁ荧光试?/span>—特异性强的染色剂

                百灵威新型生化染色
                和染?/span>

                百灵威核心生化试?/span>

                ??/span> 总共1?/span>